Acute arsenic exposure induces inflammatory responses and CD4⁺ T cell subpopulations differentiation in spleen and thymus with the involvement of MAPK, NF-kB, and Nrf2

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• 作者：Xiaoxu Duan^a ; ¹ ; Shuang Gao^b ; ¹ ; Jinlong Li^a ; Liuzhong Wu^c ; Yang Zhang^a ; Wei Li^a ; Lu Zhao^a ; Jinli Chen^a ; Shan Yang^a ; Guifan Sun^a ; Bing Li^a ; ^{bli10@cmu.edu.cn}
• 关键词：TNF-α ; tumor necrosis factor α ; ROS ; reactive oxygen species ; NF-kB ; nuclear factor kappa B ; MAPK ; mitogen-activated protein kinase ; ERK1/2 ; extracellular-signal-regulated kinases 1/2 ; JNK ; c-Jun N-terminal kinases ; Nrf2 ; nuclear factor E2-related factor 2 ; Gata3 ; GATA-binding protein 3 ; IFN-γ ; interferon gamma ; HO-1 ; heme oxygenase-1 ; MPO ; myeloperoxidase ; MDA ; malondialdehyde ; H2O2 ; hydrogen peroxide ; CAT ; catalase ; GSH-Px ; glutathione peroxidase ; GST ; glutathione-S-transferase ; Treg cells ; re
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：81
• 期：Complete
• 页码：160-172
• 全文大小：5150 K
• 卷排序：81

文摘

Arsenic induced inflammatory responses in immune organs. Arsenic affected CD4+ T cells differentiation in immune organs. Arsenic mediated oxidative injuries in immune organs. Arsenic activated MAPK, NF-kB and Nrf2 pathway in immune organs.