Downregulation of autophagy gene expression in endometria from women with polycystic ovary syndrome

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• 作者：Mirjana Sumarac-Dumanovic^a ; ^b ; Milica Apostolovic^b ; Kristina Janjetovic^c ; Danka Jeremic^a ; Dusan Popadic^d ; Aleksandar Ljubic^e ; Jelena Micic^b ; ^f ; Jelena Dukanac-Stamenkovic^b ; ^f ; Aleksandra Tubic^g ; Darko Stevanovic^h ; Dragan Micic^b ; ^{dragan.micic@med.bg.ac.rs} ; Vladimir Trajkovic^d ; ^{vtrajkovic@med.bg.ac.rs}
• 关键词：Polycystic ovary syndrome ; Endometrium ; Autophagy ; Autophagy-related genes ; Free androgen index
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：440
• 期：Complete
• 页码：116-124
• 全文大小：876 K
• 卷排序：440

文摘

Endometrial expression of several autophagy-related genes is reduced in PCOS. Free androgen index negatively correlates with autophagy gene expression in PCOS. Metformin treatment partly restores autophagy gene expression in PCOS endometrium.