Host Epac1 is required for cAMP-mediated invasion by Trypanosoma cruzi

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• 作者：Daniel Musikant^a ; Gabriel Ferri^a ; Ignacio M. Durante^b ; Carlos A. Buscaglia^b ; Daniel L. Altschuler^c ; ^{altschul@pitt.edu} ; Martin M. Edreira^a ; ^c ; ^{mme2@pitt.edu}
• 关键词：Trypanosoma cruzi ; Invasion ; cAMP ; Epac ; PKA
• 刊名：Molecular and Biochemical Parasitology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：211
• 期：Complete
• 页码：67-70
• 全文大小：835 K
• 卷排序：211

文摘

Epac1 is the key mediator of T. cruzi cAMP-dependent host cell invasion. Epac1 localization would be required for cAMP-mediated modulation of invasion. PKA-mediated inhibition of the Epac pathway increased negatively modulates invasion.