TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway

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• 作者：Wenchun Fan^a ; ^b ; Tingting Liu^a ; ^b ; Xiangmin Li^a ; ^b ; ^c ; Yun Zhou^a ; ^b ; Mengge Wu^a ; ^b ; Xiaofang Cui^a ; ^b ; Huanchun Chen^a ; ^b ; ^c ; Ping Qian^a ; ^b ; ^c ; ^{qianp@mail.hzau.edu.cn}
• 关键词：TRIM52 ; Nuclear factor-kappa B (NF-κB) ; Signaling transduction ; Pro-inflammatory cytokine
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：82
• 期：Complete
• 页码：114-122
• 全文大小：1848 K
• 卷排序：82

文摘

TRIM52 selectively activates NF-κB activity. RING-domain is essential for TRIM52-mediated NF-κB activation. TRIM52 overexpression do not affect the changes in IκBα and phosphorylated p6 protein levels. NF-κB inhibitors have no effect on TRIM52-mediated NF-κB activation. TRIM52 mRNA expression was induced by pro-inflammatory cytokines.