Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation

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• 作者：Li Ma¹ ; ³ ; ¹⁰ ; Chao Huang¹ ; ² ; ¹⁰ ; ^{c_huang_bio@msn.com} ; Xiong-Jun Wang¹ ; ¹⁰ ; Dazhuan Eric Xin¹ ; ¹⁰ ; Li-shun Wang¹ ; Quanli C. Zou¹ ; Ya-nan S. Zhang¹ ; Min-dian Tan¹ ; Yu-mei Wang¹ ; Ting C. Zhao³ ; Devasis Chatterjee³ ; Rachel A. Altura³ ; Chuangui Wang⁴ ; Yan S. Xu⁵ ; Jing-hua Yang⁵ ; Yong-sheng Fan⁶ ; Bao-hui Han² ; Jianmin Si⁷ ; Xiaoren Zhang¹ ; Jinke Cheng⁸ ; Zhijie Chang⁹ ; ^{zhijiec@tsinghua.edu.cn} ; Y. Eugene Chin¹ ; ¹¹ ; ^{yechin@sibs.ac.cn}
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：65
• 期：2
• 页码：296-309
• 全文大小：5943 K
• 卷排序：65

文摘

Loxl3 catalyzes Stat3 deacetylation coupled with deacetylimination SRCR repeats of Loxl3 bear the major deacetylase activity on Stat3 in nuclei Loxl3 disrupts Stat3 dimerization and inhibits Stat3 transcriptional activity The Loxl3-Stat3 pathway controls inflammatory responses