TRAIL facilitates cytokine expression and macrophage migration during hypoxia/reoxygenation via ER stress-dependent NF-κB pathway

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• 作者：Yinan Jiang^a ; Xiaoyan Chen^b ; Mengya Fan^b ; Hui Li^b ; Weina Zhu^b ; Xi Chen^b ; Chenghua Cao^b ; Rui Xu^b ; Yaohui Wang^b ; ^{wangyaohui2001@sina.com} ; Yuanfang Ma^a ; ^b ; ^{mayf@henu.edu.cn}
• 关键词：TRAIL ; Tumor necrosis factor-related apoptosis-inducing ligand ; I/R ; Ischemia and reperfusion ; H/R ; Hypoxia and reoxygenation ; CAPE ; Cafifeic Acid Phenethyl Ester ; ER stress ; Endoplasmic reticulum stress ; Neutr Ab ; Neutralizing antibody ; ARVMs ; adult rat ventricular myocytes
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：82
• 期：Complete
• 页码：123-136
• 全文大小：5106 K
• 卷排序：82

文摘

TRAIL facilitated macrophage inflammatory factors production macrophage migration after hypoxia and reperfusion. Production of macrophage cytokines induced by TRAIL dependent on activation of NF-κB and ER stress pathway. ER stress signaling pathway contributed to the activation of the NF-κB signaling pathway.