Wall teichoic acid is an essential component of Staphylococcus aureus for the induction of human dendritic cell maturation

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• 作者：Sung Jun Hong^a ; ¹ ; ² ; Sun Kyung Kim^a ; ¹ ; Eun Byeol Ko^a ; Cheol-Heui Yun^b ; ^c ; Seung Hyun Han^a ; ^{shhan-mi@snu.ac.kr}
• 关键词：DC ; dendritic cell ; EKSA ; ethanol-killed Staphylococcus aureus ; MAMP ; microbe-associated molecular pattern ; MFI ; mean fluorescence intensity ; WTA ; wall teichoic acid ; ZPS ; zwitterionic polysaccharides
• 刊名：Molecular Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：81
• 期：Complete
• 页码：135-142
• 全文大小：993 K
• 卷排序：81

文摘

S. aureus and wall teichoic acid (WTA)-deficient mutant were compared in activation of human DCs. WTA-deficient S. aureus induced phenotypic maturation of DC less potently than the wild-type. WTA-deficient S. aureus weakly induced cytokine expression in comparison with the wild-type. WTA-deficient S. aureus minimally enhances T lymphocyte-activating capacity of DCs. WTA might be an important component of S. aureus provoking human DC maturation and activation.