Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults

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• 作者：Mathew Van de Pette¹ ; Allifia Abbas¹ ; Amelie Feytout¹ ; Gr&aacute ; inne McNamara¹ ; Ludovica Bruno¹ ; Wilson K. To¹ ; Andrew Dimond¹ ; Alessandro Sardini¹ ; Zoe Webster¹ ; James McGinty² ; Eleanor J. Paul¹ ; Mark A. Ungless¹ ; Paul M.W. French² ; Dominic J. Withers¹ ; Anthony Uren¹ ; Anne C. Ferguson-Smith³ ; Matthias Merkenschlager¹ ; Rosalind M. John⁴ ; Amanda G. Fisher¹ ; ⁵ ; ^{amanda.fisher@lms.mrc.ac.uk}
• 关键词：imprinting ; Cdkn1c ; environmental stress ; bioluminescence ; luciferase reporter mice
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1090-1099
• 全文大小：3730 K
• 卷排序：18

文摘

Allele-specific expression of imprinted Cdkn1c imaged in vivo using bioluminescence Chromatin-modifying drugs applied in utero transiently de-repress Cdkn1c imprinting In utero exposure to low-protein diet permanently disrupts the Cdkn1c imprint Folate supplements during gestation protect against loss of Cdkn1c imprinting