Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson’s Disease

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• 作者：Li Song¹ ; ² ; ³ ; ⁶ ; Yijing He⁴ ; ⁶ ; Jiayao Ou¹ ; ² ; ³ ; Yongbo Zhao¹ ; ² ; ³ ; Ruoyu Li¹ ; ² ; ³ ; Jingjing Cheng¹ ; ² ; ³ ; Chin-Hsien Lin⁵ ; Margaret S. Ho¹ ; ² ; ³ ; ⁷ ; ^{margaret_ho@tongji.edu.cn}
• 关键词：Parkinson&rsquo ; s disease ; PD ; cyclin-G-associated kinase ; GAK ; auxilin ; aux ; dopaminergic neuron loss ; DA ; α-synuclein ; paraquat ; locomotor deficits ; longevity
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1132-1143
• 全文大小：5201 K
• 卷排序：18

文摘

Reduced aux expression causes reduced locomotion and longevity in flies Reduced aux expression causes age-dependent DA neuron loss at the PPM1/2 cluster Reduced aux expression enhances and accelerates α-Syn-mediated DA neuron loss aux expression in DA neurons alters paraquat sensitivity in flies