Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing

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• 作者：Yong Zhang¹ ; ⁶ ; Monique N. O&rsquo ; Leary² ; ⁶ ; Suraj Peri¹ ; Minshi Wang¹ ; Jikun Zha¹ ; Simon Melov² ; Dietmar J. Kappes¹ ; Qing Feng³ ; Jennifer Rhodes¹ ; Paul S. Amieux⁴ ; David R. Morris⁵ ; Brian K. Kennedy² ; David L. Wiest¹ ; ⁷ ; ^{david.wiest@fccc.edu}
• 关键词：ribosomal protein ; paralog ; morphogenesis ; gastrulation ; extraribosomal function ; Rpl22 ; Rpl22l1 ; pre-mRNA splicing ; Smad2 ; hnRNP-A1
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：545-556
• 全文大小：3519 K
• 卷排序：18

文摘

Ribosomal proteins Rpl22 and Like1 antagonistically control morphogenesis During gastrulation, Rpl22 and Like1 act away from the ribosome in the nucleus Rpl22 and Like1 control gastrulation by regulating the splicing of Smad2 pre-mRNA Control of gastrulation by Rpl22 and Like1 involves cooperation with HNRNP-A1