Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma

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• 作者：Dinesh K. Singh¹ ; ² ; ³ ; ¹² ; ¹³ ; Rahul K. Kollipara³ ; ¹² ; Vamsidara Vemireddy¹ ; ² ; Xiao-Li Yang¹ ; ² ; Yuxiao Sun¹ ; ² ; Nanda Regmi¹ ; ² ; Stefan Klingler⁴ ; Kimmo J. Hatanpaa² ; ⁵ ; Jack Raisanen² ; ⁵ ; Steve K. Cho¹ ; ² ; Shyam Sirasanagandla² ; ⁶ ; Suraj Nannepaga¹ ; ² ; Sara Piccirillo¹ ; Tomoyuki Mashimo² ; ⁶ ; Shan Wang³ ; Caroline G. Humphries³ ; Bruce Mickey² ; ⁷ ; Elizabeth A. Maher¹ ; ² ; ⁶ ; ⁸ ; Hongwu Zheng⁴ ; Ryung S. Kim⁹ ; Ralf Kittler³ ; ⁸ ; ¹⁰ ; ¹¹ ; ¹⁴ ; ^{ralf.kittler@utsouthwestern.edu} ; Robert M. Bachoo¹ ; ² ; ⁶ ; ⁸ ; ^{robert.bachoo@utsouthwestern.edu}
• 关键词：astrocyte ; brain ; cancer ; glioblastoma ; oncogene ; stem cells ; targeted therapy ; transcription factor
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：24 January 2017
• 年：2017
• 卷：18
• 期：4
• 页码：961-976
• 全文大小：10857 K
• 卷排序：18

文摘

Sox2, Olig2, and Zeb1 expression is increased in glioma-initiating cells These transcription factors are expressed irrespective of putative GBM oncogenes Sox2, Olig2, and Zeb1 expression transforms tumor-suppressor-deficient astrocytes Mithramycin inhibits Sox2, Olig2, and Zeb1 expression and GBM cell proliferation