TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation

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• 作者：Daniel B. Graham¹ ; ² ; ³ ; ^{dgraham@broadinstitute.org} ; Ariel Lefkovith¹ ; Patrick Deelen⁴ ; Niek de Klein⁴ ; Mukund Varma¹ ; Angela Boroughs⁵ ; A. Nicole Desch¹ ; Aylwin C.Y. Ng³ ; Gaelen Guzman¹ ; Monica Schenone¹ ; Christine P. Petersen¹ ; Atul K. Bhan⁶ ; Manuel A. Rivas¹ ; Mark J. Daly¹ ; ⁷ ; Steven A. Carr¹ ; Cisca Wijmenga⁴ ; Ramnik J. Xavier¹ ; ² ; ³ ; ⁵ ; ⁸ ; ⁹ ; ^{xavier@molbio.mgh.harvard.edu}
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：17
• 期：11
• 页码：2955-2965
• 全文大小：3396 K
• 卷排序：17

文摘

Functional genetics implicates TMEM258 in inflammatory bowel disease TMEM258 interacts with RPN1 in the oligosaccharyltransferase (OST) complex Compromised OST function in the absence of TMEM258 impairs protein glycosylation Mouse models of TMEM258 deficiency show ER stress and intestinal pathology