Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons

详细信息    查看全文

• 作者：Giorgia Bartolini¹ ; ³ ; ⁴ ; ⁵ ; Juan Antonio Sá ; nchez-Alcañ ; iz³ ; ⁴ ; ⁶ ; Catarina Osó ; rio¹ ; ² ; Manuel Valiente³ ; ⁷ ; Cristina Garcí ; a-Frigola³ ; Oscar Marí ; n¹ ; ² ; ³ ; ⁸ ; ^{oscar.marin@kcl.ac.uk}
• 关键词：cerebral cortex ; interneuron ; migration ; neuregulins ; lamination ; Erbb4 ; GABA ; inhibition ; cortical plate ; pyramidal cell
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1157-1170
• 全文大小：4998 K
• 卷排序：18

文摘

Nrg3 acts a short-range chemoattractive molecule for cortical interneurons Nrg3 functions through ErbB4 to attract interneurons into the cortical plate Interneurons prefer Cxcl12 over Nrg3 during tangential migration Disruption of Nrg3 signaling causes abnormal interneuron lamination in the cortex