Primary Human Testicular Cells Self-Organize into Organoids with Testicular Properties

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• 作者：Yoni Baert¹ ; ^{yoni.baert@vub.ac.be} ; Joery De Kock² ; Joã ; o P. Alves-Lopes³ ; Olle Sö ; der³ ; Jan-Bernd Stukenborg³ ; ⁴ ; Ellen Goossens¹ ; ⁴
• 关键词：spermatogonia ; testis ; scaffold ; organoid ; in vitro spermatogenesis ; whole mount ; immunofluorescence ; secretome ; testosterone ; inhibin B
• 刊名：Stem Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：30-38
• 全文大小：3708 K
• 卷排序：8

文摘

Primary human testicular cells form organoids regardless of scaffold support The testis-specific cytoarchitecture was not restored in testicular organoids Active niche cells and spermatogonia were maintained in testicular organoids Testicular organoids might help achieving human spermatogenesis in vitro