The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1β Secretion by Inflammasomes

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• 作者：Matthew J.G. Eldridge¹ ; Julia Sanchez-Garrido¹ ; Gil Ferreira Hoben¹ ; Philippa J. Goddard¹ ; Avinash R. Shenoy¹ ; ² ; ^{a.shenoy@imperial.ac.uk}
• 关键词：inflammasomes ; caspase-1 ; IL-1β ; UBE2L3 ; ubiquitin ; proteasome ; caspase-4 ; Salmonella ; Listeria ; commensals
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1285-1297
• 全文大小：3428 K
• 卷排序：18

文摘

Caspase-1 inflammasomes induce loss of UBE2L3 in macrophages and dendritic cells UBE2L3 loss is proteasome-dependent, ubiquitin- and pyroptosis-independent UBE2L3 participates in K48 ubiquitylation and proteasomal turnover of pro-IL-1β UBE2L3 modulates levels of pro-IL-1β available for processing by caspase-1