Protection against High-Fat-Diet-Induced Obesity in MDM2^C305F Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure

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• 作者：Shijie Liu¹ ; ² ; ⁵ ; Tae-Hyung Kim¹ ; ² ; ⁵ ; Derek A. Franklin¹ ; ² ; ³ ; Yanping Zhang¹ ; ² ; ³ ; ⁴ ; ⁶ ; ^{ypzhang@med.unc.edu}
• 关键词：ribosomal protein ; MDM2 ; p53 ; high-fat diet ; NAD+ ; energy expenditure
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：24 January 2017
• 年：2017
• 卷：18
• 期：4
• 页码：1005-1018
• 全文大小：3913 K
• 卷排序：18

文摘

Mdm2C305F mice exhibit longer lifespan and are resistant to HFD-induced obesity HFD induces MYC- and RPL11-dependent p53 expression in WT but not Mdm2C305F mice Lower p53 activity in HFD-fed Mdm2C305F mice increases levels of GLUT4 and SIRT1 Increased GLUT4 and SIRT1 enhances NAD+ biosynthesis and energy expenditure