Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation

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• 作者：Sreerama Chaitanya Sridhara¹ ; Sí ; lvia Carvalho¹ ; Ana Rita Grosso¹ ; Lina Marcela Gallego-Paez¹ ; Maria Carmo-Fonseca¹ ; Sé ; rgio Fernandes de Almeida¹ ; ² ; ^{sergioalmeida@fm.ul.pt}
• 关键词：R-loops ; genomic instability ; transcription dynamics ; RNA polymerase II ; DDX23 ; SRPK2
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：334-343
• 全文大小：3640 K
• 卷排序：18

文摘

Loss of DDX23 triggers RNA-mediated genomic instability Phosphorylation of DDX23 by SRPK2 is necessary to suppress R-loops Pausing of RNA polymerase II nucleates DDX23 at sites of R-loop formation Homozygous deletions of DDX23 are frequent in adenoid cystic carcinoma