RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells

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• 作者：Harry O. King¹ ; Tim Brend¹ ; Helen L. Payne¹ ; Alexander Wright¹ ; Thomas A. Ward¹ ; Karan Patel¹ ; Teklu Egnuni¹ ; Lucy F. Stead¹ ; Anjana Patel¹ ; Heiko Wurdak¹ ; Susan C. Short¹ ; ^{s.c.short@leeds.ac.uk}
• 关键词：RAD51 ; glioblastoma ; radiosensitization ; glioma stem cell
• 刊名：Stem Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：125-139
• 全文大小：3755 K
• 卷排序：8

文摘

RAD51 is overexpressed in glioma stem cells RAD51 expression levels fall when GSCs are differentiated RAD51 inhibitors abrogate DNA repair leading to radiosensitization in GSCs RAD51 inhibition + XR removes SOX2-expressing cells and abolishes clonogenicity