The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3

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• 作者：Jacob A. McPhail¹ ; Erik H. Ottosen¹ ; Meredith L. Jenkins¹ ; John E. Burke¹ ; ² ; ^{jeburke@uvic.ca}
• 关键词：lipid signaling ; phosphatidylinositol 4 kinase ; PI4K ; PI4KB ; ACBD3 ; phosphoinositide ; X-ray crystallography ; hydrogen-deuterium exchange mass spectrometry ; HDX-MS ; picornaviruses
• 刊名：Structure
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：121-131
• 全文大小：2045 K
• 卷排序：25

文摘

PI4KIIIβ/ACBD3/Aichi 3A reconstitution reveals direct activation of PI4KIIIβ by 3A ACBD3 sensitizes 3A-PI4KIIIβ activation, designed mutations disrupt complex HDX-MS defines the binding interfaces of ACBD3-PI4KIIIβ and 3A-ACBD3 Crystal structure of ACBD3 GOLD domain reveals a unique N terminus that binds with 3A