Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility

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• 作者：Joana V. Flores¹ ; Lucí ; a Cordero-Espinoza¹ ; ² ; ⁵ ; Feride Oeztuerk-Winder¹ ; ³ ; Amanda Andersson-Rolf¹ ; Tommaso Selmi¹ ; ³ ; Sandra Blanco¹ ; ³ ; Jignesh Tailor⁴ ; Sabine Dietmann¹ ; Michaela Frye¹ ; ³ ; ^{mf364@cam.ac.uk}
• 关键词：neurodevelopmental disorder ; RNA methylation ; 5-methylcytosine ; NSUN2 ; neural stem cells
• 刊名：Stem Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：112-124
• 全文大小：4202 K
• 卷排序：8

文摘

NSUN2 marks early neuroepithelial progenitors in the developing human brain Loss of NSUN2 causes microcephaly by reduction of upper-layer neurons in the cortex Loss of NSUN2 in neuroepithelial stem cells impairs migration and differentiation