Maternal Metabolism and Vascular Adaptation in Pregnancy: The PPAR Link

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• 作者：Ruth Ganss¹ ; ^@ ; ^{ganss@perkins.uwa.edu.au}
• 关键词：pregnancy ; preeclampsia ; PPAR ; metabolism ; RGS5 ; blood vessel
• 刊名：Trends in Endocrinology & Metabolism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：28
• 期：1
• 页码：73-84
• 全文大小：1928 K
• 卷排序：28

文摘

Current therapies for pregnancy-related hypertension and its complications remain inadequate, although an increasing role for maternal susceptibility is becoming evident. Systemic vascular dysfunction in response to imbalances in angiogenic, inflammatory, and constricting factors is implicated in the pathogenesis of gestational hypertension, and growing evidence now links these factors with maternal metabolism. In particular, the crucial role of peroxisome proliferator-activated receptors (PPARs) in maternal vascular adaptation provides further insights into how obesity and gestational diabetes may be linked to pregnancy-induced hypertension and preeclampsia. This is especially important given the rapidly growing prevalence of obesity during pregnancy, and highlights a new approach to treat pregnancy-related hypertension and its complications.