Structural Insights into Linear Tri-ubiquitin Recognition by A20-Binding Inhibitor of NF-κB, ABIN-2

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• 作者：Shan-Meng Lin¹ ; Su-Chang Lin² ; Jhen-Yi Hong¹ ; Tsung-Wei Su² ; Bai-Jiun Kuo¹ ; Wei-Hsin Chang¹ ; Yi-Fan Tu¹ ; Yu-Chih Lo¹ ; ³ ; ⁴ ; ⁵ ; ⁶ ; ^{gracelo@mail.ncku.edu.tw}
• 关键词：A20 ; ABINs ; linear polyubiquitin ; UBAN ; ubiquitin-binding domain ; signaling complex
• 刊名：Structure
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：66-78
• 全文大小：4610 K
• 卷排序：25

文摘

Crystal structure of hABIN2 in complex with linear tri-ubiquitin with a 2:1 ratio hABIN2 preferentially uses the primary Ub-binding site to bind a tri-ubiquitin A tri-ubiquitin molecule bridges two hABIN2 dimers at a high protein concentration A helical arrangement of linear polyubiquitin allows a higher-order complex assembly