Pro-apoptotic cBid and Bax exhibit distinct membrane remodeling activities: An AFM study

详细信息    查看全文

• 作者：Joseph D. Unsay^a ; ^b ; ^c ; ¹ ; Katia Cosentino^a ; ^b ; ¹ ; Katharina Sporbeck^a ; Ana J. Garcí ; a-Sá ; ez^a ; ^b ; ^{ana.garcia@uni-tuebingen.de}
• 关键词：Atomic force microscopy (AFM) ; Bcl-2 proteins ; Force spectroscopy ; Membrane ; supported lipid bilayers
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1859
• 期：1
• 页码：17-27
• 全文大小：1815 K
• 卷排序：1859

文摘

cBid decreases the breakthrough force of CL-containing supported lipid structures. cBid lowers the thickness of SLSs in CL-rich lipid structures. Oligomeric Bax lowers the breakthrough force of supported lipid structures. cBid and Bax distinctly and independently affect membrane physical properties.