The significant effect of chronic intermittent hypoxia on prostaglandin D₂ biosynthesis in rat brain

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• 作者：Li-na Shan^a ; Wen-shu Chai^a ; Si-jing Lu^a ; Yong-gui Song^b ; Dan Su^b ; Shuman Yang^c ; ^d ; Xian-bao Shi^a ; ^{sxbsln@163.com} ; Wei Wang^e ; ^{wwbycmu2@126.com}
• 关键词：Chronic intermittent hypoxia ; Sleep apnea ; Prostaglandin D2 ; Prostaglandin D2 synthase ; LC-MS/MS
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：283-287
• 全文大小：577 K
• 卷排序：483

文摘

An UPLC–MS/MS method for determination of prostaglandin D2 in rat brain was established. CIH increases the concentration of PGD2 in rat brain. CIH increases the protein and mRNA expressions in rat brain.