pKa values of hyodeoxycholic and cholic acids in the binary mixed micelles sodium-hyodeoxycholate-Tween 40 and sodium-cholate-Tween 40: Thermodynamic stability of the micelle and the cooperative hydrogen bond formation with the steroid skeleton

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• 作者：Mihalj Po&scaron ; a ; ^{mihaljp@uns.ac.rs} ; Ana Pilipović ; Mirjana Bećarević ; Zita Farka&scaron
• 关键词：Mixed micelles ; Regular Solution Theory ; Bile acids ; Excess Gibbs energy
• 刊名：Steroids
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：117
• 期：Complete
• 页码：62-70
• 全文大小：1394 K
• 卷排序：117

文摘

For bile acids HD and C pKa values increase in mixed micelles with Tween 40. Increase of ΔpKa of HD and C related to pKa of free HD and C is a measure of mixed micelles stability. H-bonds between steroids OH-Tween 40 polyoxyethylene groups: aggregate stability. Cooperative hydrogen bond formation between HD and Tween 40.