Histone methyltransferase Setdb1 is indispensable for Meckel's cartilage development

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• 作者：Kohei Yahiro ; Norihisa Higashihori ; ^{n-higashihori.mort@tmd.ac.jp} ; Keiji Moriyama
• 关键词：Setdb1 ; Histone methyltransferase ; Epigenetic ; Craniofacial development ; Meckel's cartilage ; BMP
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：883-888
• 全文大小：2679 K
• 卷排序：482

文摘

Deletion of Setdb1 led to enlarged Meckel's cartilage. Chondrocytes from the Meckel's cartilage of Setdb1 mutant showed increased in size. Part of the perichondrium was disrupted and mineralization was observed in the Meckel's cartilage of Setdb1 mutant. Deletion of Setdb1 increases proliferation in vivo and in vitro. Deletion of Setdb1 enhances SMAD-dependent BMP signaling in vivo and in vitro.