The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking

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• 作者：Hyejin Kim^a ; Younghwa Chun^a ; Lihua Che^a ; Jeongbeom Kim^a ; Sungjoong Lee^b ; Soojin Lee^a ; ^{leesoojin@cnu.ac.kr}
• 关键词：Neuronal growth regulator 1 ; Niemann-Pick disease ; Type C2 ; Lipid raft ; Cholesterol ; Obesity
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1367-1374
• 全文大小：1753 K
• 卷排序：482

文摘

NEGR1 interacts with NPC2, a key player in intracellular cholesterol trafficking. NEGR1 co-localizes with NPC2 in the late endosomes and increases NPC2 stability. NEGR1 overexpression relieved cholesterol accumulation in endosomal compartments. These findings provide the first insight into the role of NEGR1 in intracellular cholesterol homeostasis and human obesity.