MyD88 NEDDylation negatively regulates MyD88-dependent NF-κB signaling through antagonizing its ubiquitination

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• 作者：Fangxue Yan^a ; ^b ; ¹ ; Junhong Guan^a ; ^b ; ¹ ; Yanyan Peng^a ; ^b ; Xiaofeng Zheng^a ; ^b ; ^{xiaofengz@pku.edu.cn}
• 关键词：MyD88 NEDDylation ; Ubiquitination ; NEDP1 ; IL-1β ; NF-κB
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：632-637
• 全文大小：1015 K
• 卷排序：482

文摘

NEDD8 targets MyD88 for NEDDylation. NEDDylation of MyD88 antagonizes its ubiquitination, and vice versa. MyD88 NEDDylation decreases in response to IL-1β stimulation. NEDD8 regulates MyD88 ubiquitination in response to IL-1β. NEDD8 reduces MyD88 dimerization and downregulates NF-κB activity.