TET1-GPER-PI3K/AKT pathway is involved in insulin-driven endometrial cancer cell proliferation

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• 作者：Bing-ying Xie^a ; ¹ ; Qiao-ying Lv^a ; ¹ ; Cheng-cheng Ning^a ; Bing-yi Yang^a ; Wei-wei Shan^a ; Ya-li Cheng^a ; Chao Gu^a ; Xue-zhen Luo^a ; Zhen-bo Zhang^b ; Xiao-jun Chen^a ; ^{xiaojunchen2013@sina.com} ; Xiao-wei Xi^b ; ^{xixiaowei66@yahoo.com.cn} ; You-ji Feng^b
• 关键词：Insulin resistance ; Endometrial cancer ; GPER ; PI3K/AKT ; TET1
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：857-862
• 全文大小：2041 K
• 卷排序：482

文摘

GPER acts as an oncogene to drive EC cell growth in insulin resistance context. TET1 is associated with insulin-induced GPER expression. Insulin resistance contributed to EC through TET1-GPER-PI3K/AKT pathway.