Synthesis and anticancer study of 9-aminoacridine derivatives

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• 作者：Puneet Kumar^a ; ^b ; ^{puneetsoni1984@gmail.com} ; Rajesh Kumar^a ; Deo Nandan Prasad^a
• 关键词：9-Aminoacridine ; Lung cancer ; Cervical cancer ; DLA ; MTT assay
• 刊名：Arabian Journal of Chemistry
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：6
• 期：1
• 页码：79-85
• 全文大小：795 K

文摘

Acridine and its derivatives, well known as DNA intercalates lead to cell cycle arrest and apoptosis. 9-Aminoacridine derivatives were synthesized, characterized and evaluated against lung cancer (A-549) cell line and cervical cancer (HeLa) cell line by MTT assay. Compound 9 exhibited potent anticancer activity with CTC₅₀ (13.75 & 18.75 ¦Ìg/ml) for cervical cancer cell (HeLa) line and lung cancer cell (A-549) line respectively. In vitro short term cytotoxicity evaluation of compound 9 was carried out by Dalton¡¯s Lymphoma Ascites (DLA) with percentage growth inhibition CTC₅₀ (337.5 ¦Ìg/ml). Compound 7 also exhibited good anticancer activity with CTC₅₀ (31.25 & 36.25 ¦Ìg/ml) for cervical cancer cell (HeLa) line and lung cancer cell (A-549) line respectively. Further in vivo study of newly synthesized 9-aminoacridine derivative can give a ray of light in the field of anticancer drugs.