Subcellular localization of leptin and leptin receptor in breast cancer detected in an electron microscopic study

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• 作者：Saad M. Al-Shibli^a ; Nasser M. Amjad^b ; Muna K. Al-Kubaisi^c ; Shaikh Mizan^a ; ^{shaikhmizan2015@gmail.com}
• 关键词：Breast cancer ; Leptin ; Leptin receptor ; Subcellular localization ; Immunohistochemistry ; Immunocytochemistry
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1102-1106
• 全文大小：1952 K
• 卷排序：482

文摘

Leptin-leptin receptor complex is localized mostly in and around the nucleus. Nucleus might be the final seat of action of leptin-leptin receptor complex. Immunohistochemistry can prove over-expression of leptin receptor, not of leptin. Over-expression of leptin receptor is of primary importance in breast cancer.