Gene delivery of apoptin-derived peptide using an adeno-associated virus vector inhibits glioma and prolongs animal survival

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• 作者：Xiuli Zhong^a ; ¹ ; Hengyu Zhao^b ; ¹ ; Songhe Liang^a ; DanYang Zhou^a ; Wenjia Zhang^b ; Lijie Yuan^a ; ^{yuanlijie1225@163.com}
• 关键词：AAV2 ; HSP70 ; Apoptin ; Glioma ; Apoptin-derived-peptide (ADP)
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：482
• 期：3
• 页码：506-513
• 全文大小：2198 K
• 卷排序：482

文摘

An AAV vector for intracranial delivery of the secreted HSP70-targeted peptide APOPTIN derived from Apoptin to GBM tumors was designed. In U87MG and U251MG cells, conditioned medium from AAV2-apoptin-derived peptide (ADP)-expressing cells induced 83% and 78% cell death. In mice bearing intracranial U87MG tumors treated with AAV2-ADP, treatment resulted in a significant decrease in tumor growth and longer survival in mice bearing orthotopic invasive GBM brain tumors.