Protein toxins of the Echis coloratus viper venom directly activate TRPV1

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• 作者：Matan Geron ; Rakesh Kumar ; Henry Matzner ; Adi Lahiani ; Galit Gincberg ; Gadi Cohen ; Philip Lazarovici ; Avi Priel ; ^{avip@ekmd.huji.ac.il}
• 关键词：2-APB ; 2-aminoethoxydiphenyl borate ; Cap ; capsaicin ; DkTx ; double-knot toxin ; HPLC ; high performance liquid chromatography ; HEK293 ; human embryonic kidney cells 293 ; NGF ; nerve growth factor ; TRPV1 ; Transient Receptor Potential Vanilloid 1 ; TG ; trigeminal ganglia ; VaTx ; vanilloid toxin ; VBS ; vanilloids binding site
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1861
• 期：3
• 页码：615-623
• 全文大小：981 K
• 卷排序：1861

文摘

The snake venom from Echis coloratus contains peptides that target TRPV1. TRPV1 activation by this venom is not mediated by known toxins' binding sites. Snake venom elicits pain by directly activating pain receptors. The NGF presence in the venom suggests synergistic effect between its components.