MiR-148a and miR-152 reduce tamoxifen resistance in ER+ breast cancer via downregulating ALCAM

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• 作者：Ming-Jenn Chen^a ; ^b ; ¹ ; Ya-Min Cheng^c ; ¹ ; Chien-Chung Chen^d ; Yu-Chieh Chen^e ; Ching-Ju Shen^e ; ^f ; ^{chenmed.tw@yahoo.com.tw}
• 关键词：MiR-148a ; miR-152 ; Breast cancer ; Tamoxifen ; ALCAM
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：483
• 期：2
• 页码：840-846
• 全文大小：2042 K
• 卷排序：483

文摘

ALCAM upregulation is associated with tamoxifen resistance in ER + breast cancer cells. ALCAM modulates tamoxifen sensitivity in MCF-7 cells. MiR-148a and miR-152 directly target ALCAM and decrease its expression. MiR-148a and miR-152 modulate tamoxifen responses of MCF-7 cells.