miR-451 inhibits cell growth, migration and angiogenesis in human osteosarcoma via down-regulating IL 6R

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• 作者：Sheng-Yao Liu^a ; Song-Yun Deng^a ; Yong-Bin He^a ; Guo-Xin Ni^a ; ^b ; ^{liushengyao2016@163.com}
• 关键词：miR-451 ; Growth ; Migration ; Angiogenesis ; IL-6R ; Osteosarcoma
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：987-993
• 全文大小：1618 K
• 卷排序：482

文摘

Osteosarcoma (OS) has become one of the most common primary malignant tumors in the children and adolescents with a poor prognosis owing to its high malignant and metastatic potential. Although increasing evidence indicates that miR-451 could inhibit the growth and metastasis of OS, its effect on angiogenesis in OS is still very poor. What is more, the mechanism by which miR-451 affects the OS has not been fully elucidated. In the present study, miR-451 was reduced in human osteosarcoma tissues compared with the adjacent bone tissues, and the introduction of miR-451 dramatically inhibited the growth, migration and angiogenesis in OS. Additionally, it was suggested that IL 6R is a direct target gene of miR-451. Silencing of IL 6R suppressed the growth, migration and angiogenesis of OS, which was consistent with the effect of overexpression of miR-451. In conclusion, our data demonstrate that miR-451 may function as a potential suppressor of tumor growth, migration and angiogenesis in OS via down-regulating IL 6R, suggesting a promising therapeutic avenue for managing OS.