Transcriptional regulation of microsomal prostaglandin E synthase 1 by the proto-oncogene, c-myc, in the pathogenesis of inflammation and cancer

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• 作者：M. Ramanan¹ ; ^{meera.ramanan79@gmail.com} ; V.S. Pilli¹ ; G.K. Aradhyam ^{agk@iitm.ac.in} ; M. Doble ; ^{mukeshd@iitm.ac.in}
• 关键词：Cancer ; Inflammation ; Prostaglandins ; Transcription factor ; c-myc ; mPGES1
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：556-562
• 全文大小：1179 K
• 卷排序：482

文摘

c-myc binds to three E-box elements in the promoter region of mPGES1 and induces the transcription of this gene. Mutation of the proximal c-myc binding site results in considerable decrease in the promoter activity. Transfection of increasing concentrations of c-myc increases the production of PGE2. Isocoumarin analogs and Licofelone inhibit the mRNA expressions of both c-myc and mPGES1 and the production of PGE2.