刊名:Biochimica et Biophysica Acta (BBA) - General Subjects
出版年:2017
出版时间:March 2017
年:2017
卷:1861
期:3
页码:499-503
全文大小:502 K
卷排序:1861
文摘
Methotrexate is widely used as an inhibitor of dihydrofolate reductase for decades. Methotrexate affects also pathways that are independent of folate metabolism. The diverse effects of methotrexate are apparently concentration-dependent. Identification of these new targets is important for combination therapy.