Tumor-promoting effect of IL-23 in mammary cancer mediated by infiltration of M2 macrophages and neutrophils in tumor microenvironment

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• 作者：Wen Nie^a ; ¹ ; ^{wennie1228@126.com} ; Ting Yu^a ; ¹ ; Yaxiong Sang^a ; Xiang Gao^b ; ^{xiangxianggao2008@163.com}
• 关键词：Mammary cancer ; IL-23 ; Macrophage ; Neutrophil ; Inflammation
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1400-1406
• 全文大小：3878 K
• 卷排序：482

文摘

IL-23 promoted mammary tumor growth and pulmonary metastasis. IL-23 enhanced the infiltration of M2 macrophages and neutrophils into IL-23-dominated tumor microenvironment (TME). Immunosuppressing cytokines IL-10, TGF-β and VEGF were detected to rise in IL-23-transduced tumor tissues. IL-23 down regulated the ability of CD8+T and CD4+T cells to infiltrate tumors.