Interaction of an esophageal MEG protein from schistosomes with a human S100 protein involved in inflammatory response

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• 作者：Dé ; bora Orcia^a ; ¹ ; Ana Eliza Zeraik^a ; ¹ ; José ; L.S. Lopes^a ; ² ; Joci N.A. Macedo^a ; Clarissa Romano dos Santos^a ; Katia C. Oliveira^b ; ³ ; Leticia Anderson^c ; B.A. Wallace^d ; Sergio Verjovski-Almeida^c ; ^e ; Ana P.U. Araujo^a ; Ricardo DeMarco^a ; ^{rdemarco@ifsc.usp.br}
• 关键词：Synchrotron radiation circular dichroism spectroscopy ; Micro-exon gene ; Protein-protein interaction ; Intrinsically disordered proteins
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3490-3497
• 全文大小：805 K
• 卷排序：1861

文摘

Interaction of a S. mansoni MEG and a human immune-regulatory protein is described. Structural changes are detected when MEG-14 interacts with S100A9. MEG-14 interacts with S100A8/A9 dimer with lower affinity than with S100A9 homodimer. Human S100A9 specifically accumulates in the parasite esophagus when ingested.