Integrative genomic and network analysis identified novel genes associated with the development of advanced cervical squamous cell carcinoma

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• 作者：Anirban Roychowdhury^a ; ¹ ; Sudip Samadder^a ; ¹ ; Pijush Das^b ; Sapan Mandloi^b ; Sankar Addya^c ; Chandraditya Chakraborty^a ; Partha Sarathi Basu^d ; Ranajit Mondal^e ; Anup Roy^f ; Saikat Chakrabarti^b ; Susanta Roychoudhury^g ; ^{susanta@iicb.res.in} ; ^{susantarc@gmail.com} ; Chinmay Kumar Panda^a ; ^{ckpanda.cnci@gmail.com}
• 关键词：CSCC ; cervical squamous cell carcinoma ; hrHPV ; high-risk human papilloma virus ; CNVs ; copy number variations ; CGH-SNP ; comparative genomic hybridization-single nucleotide polymorphism ; TCGA ; The Cancer Genome Atlas ; PPI ; protein-protein interaction ; PARP1 ; poly-(ADP-ribose) polymerase-1 ; ATR ; ataxia telangiectasia and Rad3-related protein
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：2899-2911
• 全文大小：3125 K
• 卷排序：1861

文摘

Cervical squamous cell carcinoma (CSCC) is one of the most frequent cancers among women worldwide. Unique strategy followed by validation to understand the role of CNVs in the development of advanced cervical carcinoma High-resolution CGH-SNP microarray to identify precise CNVs in Indian patients for the first time Novel PPI network based analysis to locate proteins having biologically significant interactions Amplification and over-expression of PARP1 and ATR may play a role in development of advanced CSCC having poor prognosis.