Revealing the three dimensional architecture of focal adhesion components to explain Ca^{2 +}-mediated turnover of focal adhesions

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• 作者：Shu-Jing Chang^a ; ¹ ; Ying-Chi Chen^a ; ¹ ; Chi-Hsun Yang^a ; Soon-Cen Huang^b ; Ho-Kai Huang^a ; Chun-Chun Li^c ; Hans I-Chen Harn^d ; Wen-Tai Chiu^a ; ^d ; ^e ; ^{wtchiu@mail.ncku.edu.tw}
• 关键词：Ca2  ; + ;   ; Calpain ; Focal adhesion ; Turnover ; 3D architecture
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1861
• 期：3
• 页码：624-635
• 全文大小：3199 K
• 卷排序：1861

文摘

Degradation of focal adhesions by Ca2 +/calpain-dependent proteolysis is demonstrated. Outer FA molecules are more sensitive to calpain-mediated proteolysis. The 3D architecture of FAs is related to the dynamics of FA molecule degradation.