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Unexpected distribution of CA19.9 and other type 1 chain Lewis antigens in normal and cancer tissues of colon and pancreas: Importance of the detection method and role of glycosyltransferase regulation
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文摘
Immunofluorescence is recommended for detecting CA19.9 on tissue sections. Ratio between ST3GAL3 and B3GALT5 transcripts affects tissue expression of CA19.9. Cancer associated patterns of Lewis antigens are different in colon and pancreas. Tissue specific DNA methylation regulates B3GALT5 affecting Lewis antigen expression.

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