刊名:Biochimica et Biophysica Acta (BBA) - General Subjects
出版年:2017
出版时间:February 2017
年:2017
卷:1861
期:2
页码:256-263
全文大小:1045 K
卷排序:1861
文摘
Ten rhodium and iridium complexes were synthesized and screened. Complex 1 was identified as the first metal-based ATX inhibitor. Complex 1 engages and stabilizes purified ATX and ATX in cell lysates. Complex 1 inhibits ATX downstream signaling and shows antiproliferative activity.