Impact of dietary phytol on lipid metabolism in SCP2/SCPX/L-FABP null mice

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• 作者：Sherrelle Milligan^a ; Gregory G. Martin^a ; Danilo Landrock^a ; Avery L. McIntosh^b ; John T. Mackie^a ; Friedhelm Schroeder^b ; Ann B. Kier^a ; ^{akier@cvm.tamu.edu}
• 关键词：Obesity ; Fatty acid ; FABP ; Branched-fatty acid ; Phytol
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1862
• 期：3
• 页码：291-304
• 全文大小：1711 K
• 卷排序：1862

文摘

FABP1/SCP2/SCPx ablation (TKO) impacts liver lipids in phytol-fed female mice. TKO increased liver phospholipid and enzymes of phospholipid synthetic pathway. TKO reduced liver triacylglycerol and enzymes of triacylglycerol synthetic pathway. TKO exacerbated dietary phytol-induced whole body weight loss, especially lean tissue mass. TKO helps resolve contributions of FABP1 and SCP2/SCPx genes in female mice.