Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages

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• 作者：Neuza Domingues^a ; ¹ ; ^{neuzadomingues16@gmail.com} ; Luí ; s M.B.B. Estronca^b ; ¹ ; ^{estronca@ci.uc.pt} ; Joã ; o Silva^b ; ^{joao.silva@nms.unl.pt} ; Marisa R. Encarnaç ; ã ; o^a ; ^{marisarego@gmail.com} ; Rita Mateus^a ; ^{Rita.Mateus@unige.ch} ; Diogo Silva^c ; ^d ; ^{diogosilva@ecsaude.uminho.pt} ; Inê ; s B. Santarino^a ; ^{isantarino@gmail.com} ; Margarida Saraiva^c ; ^d ; ^{Margarida.Saraiva@ibmc.up.pt} ; Maria I.L. Soares^e ; ^{misoares@ci.uc.pt} ; Teresa M.V.D. Pinho e Melo^e ; ^{tmelo@ci.uc.pt} ; Antó ; nio Jacinto^a ; ^{antonio.jacinto@nms.unl.pt} ; Winchil L.C. Vaz^a ; ^{winchil.vaz@nms.unl.pt} ; Otí ; lia V. Vieira^a ; ^{otilia.vieira@nms.unl.pt}
• 关键词：Ox-LDL ; oxidized low-density lipoproteins ; Nat-LDL ; native LDL ; BMDM ; bone marrow derived macrophages ; ChS ; cholesteryl hemisuccinate ; FC ; free cholesterol ; LacCer ; Lactosylceramide ; LCCM ; L929-cells conditioned medium ; LUVs ; large unilamellar vesicles ; POPC ; 1-palmitoyl-2-oleoyl phosphatidylcholine ; PUFA ; polyunsaturated fatty acids
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1862
• 期：2
• 页码：210-220
• 全文大小：2398 K
• 卷排序：1862

文摘

Cholesteryl hemi-esters are triggers of: Cholesteryl hemiesters cause lysosome enlargement and malfunction in macrophages, Cholesteryl hemiesters cause inflammation in primary bone marrow derived macrophages, Cholesteryl hemiesters cause lipid accumulation in the caudal vein of Zebrafish larvae Cholesteryl hemiesters cause myeloid-cell infiltration in the caudal vein of Zebrafish larvae.