New eudesmane sesquiterpenes from Alpinia oxyphylla and determination of their inhibitory effects on microglia

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• 作者：Bei Jiang^a ; ^b ; ^&dagger ; ; Wen-Jing Wang^a ; ^b ; ^&dagger ; ; Man-Ping Li^a ; Xiao-Jun Huang^a ; ^b ; Feng Huang^a ; Hao Gao^a ; ^b ; Ping-Hua Sun^a ; Ming-Fang He^c ; Zheng-Jin Jiang^a ; Xiao-Qi Zhang^a ; ^b ; ^{xqzhang7401@yahoo.com.cn} ; Wen-Cai Ye^a ; ^b ; ^{chywc@yahoo.com.cn}
• 关键词：Alpinia oxyphylla ; Zingiberaceae ; Noreudesmane sesquiterpenoid ; Microglia ; Neuroprotection
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2013
• 出版时间：1 July, 2013
• 年：2013
• 卷：23
• 期：13
• 页码：3879-3883
• 全文大小：860 K

文摘

The fruits of Alpinia oxyphylla are used as healthcare products for the protection on neurons and prevention of dementia. Two new noreudesmane sesquiterpenoids, (5R,7S,10S)-5-hydroxy-13-noreudesma-3-en-2,11-dione (1) and (10R)-13-noreudesma-4,6-dien-3,11-dione (2), and a new eudesmane sesquiterpenoid, (5S,8R,10R)-2-oxoeudesma-3,7(11)-dien-12,8-olide (3), as well as 12 known sesquiterpenoids, were isolated from the fruits of A. oxyphylla. The structures of the new compounds (1-3) were elucidated on the basis of spectroscopic data and circular dichroism experiments. All isolates were evaluated their neuroprotective potential by inhibitory assay on nitric oxide (NO) and tumor necrosis factor-¦Á (TNF-¦Á) production in lipopolysaccharide (LPS)-induced mouse microglia BV-2 cells.