Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal

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• 作者：Le-Le Yang^a ; ¹ ; Na Xiao^a ; ¹ ; Jinfeng Liu^b ; Kang Liu^a ; Baolin Liu^a ; Ping Li^a ; Lian-Wen Qi^a ; ^{Qilw@cpu.edu.cn}
• 关键词：Baicalin (PubChem CID ; 64982) ; Scutellarin (PubChem CID ; 185617)
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1863
• 期：2
• 页码：598-606
• 全文大小：1708 K
• 卷排序：1863

文摘

Baicalin and scutellarin increase glucose disposal in vivo and in vitro. Baicalin selectively activates AMPK, while scutellarin targets Akt. Baicalin and scutellarin differentially bind to the AMPK and Akt holoenzyme. Baicalin and scutellarin synergistically enhance glucose uptake in adipocytes.