Metformin impairs systemic bile acid homeostasis through regulating SIRT1 protein levels

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• 作者：Qi Chen^a ; ^b ; ¹ ; Xiaoying Yang^a ; ¹ ; Huabing Zhang^a ; Xingxing Kong^a ; Lu Yao^a ; Xiaona Cui^a ; Yongkang Zou^a ; Fude Fang^a ; Jichun Yang^c ; Yongsheng Chang^a ; ^{changy@ibms.pumc.edu.cn}
• 关键词：Bile acid metabolism ; Deacetylate ; Foxa2 ; Metformin ; SIRT1
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1864
• 期：1
• 页码：101-112
• 全文大小：1669 K
• 卷排序：1864

文摘

Metformin interferes bile acid metabolism through decreasing SIRT1 protein levels Metformin and SIRT1 have opposite effects on bile acid metabolism in hepatocytes An increase in Foxa2 acetylation activates its activity on Cyp7a1 and slc10A1. Foxa2, at least in part, mediates the effects of metformin on bile acid metabolism