TRPV1 participates in the activation of clock molecular machinery in the brown adipose tissue in response to light-dark cycle

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• 作者：Maria Nathalia Moraes^a ; ¹ ; Nathana Mezzalira^a ; ¹ ; Leonardo Vinicius Monteiro de Assis^a ; Michael Menaker^b ; Ali Guler^b ; Ana Maria L. Castrucci^a ; ^{amdlcast@ib.usp.br}
• 关键词：Mus musculus ; Brown adipose tissue ; TrpV1 ; Ucp1 ; Clock genes ; Temperature ; Locomotor activity
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1864
• 期：2
• 页码：324-335
• 全文大小：1389 K
• 卷排序：1864

文摘

TrpV1 KO mice exhibited a reduction of locomotor activity as compared to WT mice. The oscillation of Per1, Per2 and Bmal1 in WT BAT was abolished in TrpV1 KO mice. WT mouse Ucp1 was upregulated in LD as compared to DD. In TrpV1 KO mice there was a shift of the photophase peak of Ucp1 transcript. TrpV1 KO mice showed reduced Rev-erbα expression in the scotophase.