Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation

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• 作者：Hala Guedouari^a ; Tanya Daigle^a ; Luca Scorrano^b ; ^c ; Etienne Hebert-Chatelain^a ; ^{etienne.hebert.chatelain@umoncton.ca}
• 关键词：Sirtuin 5 ; Mitochondrial fragmentation ; Mitochondrial degradation
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1864
• 期：1
• 页码：169-176
• 全文大小：990 K
• 卷排序：1864

文摘

Deletion of Sirt5 increases the levels of MiD51 and Fis1. Ablation of Sirt5 induces mitochondrial DRP1 accumulation and mitochondrial fission. Deletion of Sirt5 blocks the starvation-induced mitochondrial elongation. Sirt5 modulates mitophagy during starvation.